翟金霞

邮箱：jinxia.zhai@foxmail.com

职称：教授

办公室地址：安徽省合肥市蜀山区梅山路81号行知楼B座，230032

研究领域描述

主要从事环境内分泌干扰物的雄性生殖毒性研究。精子发生和精子质量是影响男性生育能力的重要因素。而广泛存在于外环境中的环境内分泌干扰物如何影响精子发生和精子质量的分子机制尚未完全阐明。本课题组主要围绕以十溴联苯醚为代表的环境内分泌干扰物，研究其对和男（雄）性动物的生殖毒性效应，重点关注组蛋白修饰在十溴联苯醚暴露干扰精子发生和精子质量中的分子机制。同时探索环境污染物与精液质量之间的关联性研究。并在此基础上阐明雄性生殖细胞发育异常相关的不育症等疾病的分子机理，为制定相关的防治对策和措施提供理论基础。

承担国家自然基金面上项目和安徽省自然科学基金项目等项目。发表科技论文近百篇。主要科技论文如下：

1. “BDE-209 induce spermatocytes arrest at early-pachytene stage during meiotic prophase I in mice”. Toxicology，2022. 02

2. “An increase of estrogen receptor α protein level regulates BDE-209-mediated blood-testis barrier disruption during spermatogenesis in F1 mice”. Environmental Science and Pollution Research, 2019.02

3. “Vitamin C supplementation rescued meiotic arrest of spermatocytes in Balb/c mice exposed to BDE-209”. Ecotoxicology and Environmental Safety, 2022.09

4. “N-acetylcysteine rescues meiotic arrest during spermatogenesis in mice exposed to BDE-209”. Environmental Science and Pollution Research，2023.04

5. “Polychlorinated biphenyls and risk of metabolic syndrome and comparison with the risk of diabetes: A systematic review and meta-analysis”. Science of the Total Environment, 2023.11

6. “BDE-209 disturbed proliferation and differentiation of spermatogonia during mitotic process through estrogen receptor α”. Reproductive Biology, 2023. 06

7. “Environmental and occupational exposure to cadmium associated with male reproductive health risk: a systematic review and meta-analysis based on epidemiological evidence”. Environmental Geochemistry and Health, 2023. 08

8. “Study on the association between ambient air pollution and daily cardiovascular death in Hefei, China”. Environmental Science and Pollution Research, 2020.01